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Peter trained for five years at the Johns Hopkins Hospital in general surgery, where he was the recipient of several prestigious awards, including resident of the year, and the author of a comprehensive review of general surgery. He receives neither direct nor indirect compensation from either company.
He also spent two years at NIH as a surgical oncology fellow at the National Cancer Institute where his research focused on immune-based therapies for melanoma. Peter works very closely with the following companies, but receives no compensation from any of them: Peter is an investor in the company Salutoceuticals which makes an OTC sleep aid.
For a long time this has been a tiny part of an overarching and expanding page on cholesterol that’s just become too big for it’s boots (and sadly should never have needed to be), but it seems to be something people want summarised so here it is as it’s own page.
Dr Peter Attia burst onto the scene via social media recommendations of Gary Taubes in 2011 and quickly became the science darling of cholesterol and keto and low-carb performance exercise with his in-depth yet approachable-for-semi-sciencey-type articles.
I am absolutely – perhaps pathologically – obsessed with lipidology, the science and study of lipids. Each line in this figure represents a bond between two carbon atoms. Cholesterol, a steroid alcohol, can be “free” or “unesterified” (“UC” as we say, which stands for unesterified cholesterol) which is its active form, or it can exist in its “esterified” or storage form which we call a cholesterol ester (“CE”).
The progression of atherosclerosis: an apo B containing particle gets past the artery layer, the particle and its cholesterol content is retained and oxidized, immune cells arrive, an initially-beneficial inflammatory response occurs that ultimately becomes maladaptive leading to plaque.
While inflammation plays a key role in this process, it’s the penetration of the apo B particle, with its sterol passengers, of the endothelium and retention within the sub-endothelial space that drive the process.
Cholesterol and triglycerides are not soluble in plasma.
To be carried anywhere in our body, they need to be carried by a special protein-wrapped transport vessel called a lipoprotein.
The measurement of cholesterol has undergone a dramatic evolution over the past 70 years.